This week we are talking about cellular senescence.
Cellular senescence is a process by which the cells age and permanently stop dividing but do not die. Over time, large numbers of old (or senescent) cells can build up in tissues throughout the body. These cells remain active and can release harmful substances that may cause inflammation and damage to nearby healthy cells.
The scientists found that human cells have a limited ability to reproduce by dividing. The cells divide no more than 40 to 60 times.
DNA damage and shortened telomere length is associated with cellular senescence.
Cells that are young produce proteins that maintain the structure and function of tissues keeping them in a healthy state. However, cells that are close to senescence release enzymes that break down these helpful proteins.
The accumulation of senescent cells creates inflammation in the body and is directly associated with age related diseases.
Senescent cells are associated with:
- Chronic infections
- Oxidative stress
- Sleep: Disruption in the circadian rhythm whether it may be jet lag, shift work, or insomnia can promote cellular senescence. This is why it is important to prioritize getting at least 6-7 hours of sleep each night.
- Calorie Restriction: A decrease in calories by 10-30% is associated with increased lifespan and health status.
- Exercising: For each hour of moderate exercise, studies show an increase in average life expectancy of 2 hours.
- Peptides: Research shows that certain peptides are able to promote longevity and clear senescent cells.
Here are links to articles where you can read more about cellular senescence:
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Best of Health!
You Holistic Team
149 Epping Rd
Exeter NH 03833